Histone Deacetylase Is Involved in yhe Inhibition of Tyrosine Hydroxylase Expression by α-Synuclein

来源 :第八届亚洲大洋洲地区老年学和老年医学大会 | 被引量 : 0次 | 上传用户：zhaominjie88

【摘要】

：

Objective:Accumulating evidence shows that α-synuclein (α-Syn) plays a key rolein the pathogenesis of Parkinsons disease (PD).However,the mechanism underlying the pathological role of this protein rem

【作者】

：

Xuemei Wang Shun Yu Yaohua Li Shengli Xu Kenji Uéda Piu Chan

【机构】

：

Departments of Neurobiology and Neurology and Sino-Japan Joint Laboratory for Neurodegenerative Dise

【出处】

：

第八届亚洲大洋洲地区老年学和老年医学大会

【发表日期】

：

2007年5期

【关键词】

：

α-synuclein tyrosine hydroxylase dopaminergic neurons

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

The Study of Alzheimer's Disease Animal Model Induced by Jointly Injecting Beta-Amyloid1-40 and

Alzheimers disease (AD) is a chronic,progressing neuronal degeneration disease,the etiology and pathogenesis of AD is not clear.In order to be helpful in understanding the etiology and pathogenesis of

会议

Alzheimer diseaseanimal modelbeta-amyloidaluminumtransforming growth factor

The regulation of 11 β-Hydroxysteroid Dehydrogenase Type 1 by Glucocorticoid and Interleukin-1β in t

Chronic increase of glucocorticoid level is known to play an important role in age-related neuron degeneration and poor memory.The intracellular glucocorticoid level is increased by 11β-hydroxysteroid

会议

Modulation of Mitochondrial Function and Extension of Replicative Life Span Through in Primary Human

Ongoing application of nicotirnamide to normal human fibroblasts not only attenuates expression of the aging phenotype but also increases their replicative life span,causing more than an 1.6-fold incr

会议

Superoxide Generated by NAD(P)H Oxidase Inhibits the Activation of Membrane-Bound Guanylate Cyclase

Purpose:We examined the effect of superoxide generated by NAD(P)H oxidaseon theactivation of membrane-bound guanylate cyclase GC-A by atrial natriuretic factor (ANF) in porcine kidney proximal tubular

会议

Exercise for Orthostatic Hypotension in Tamsulosinum Treated Elderly Men with Benign Prostate Hyperp

Orthostatic hypotension,often encountered in the elderly,can be induced by several factors including alteration of regulatory mechanisms originating in carotid sinus as well as by several medicines,in

会议

Role of Gravin in Insulin Resistance

Type 2 diabetes phenotypes are linked with cAMP content.cAMP is known to mitigate the metabolic actions of insulin in several cellular contexts and in several cases of physiological insulin resistance

会议

Memory Deficit and Abnormal Secretion of Corticosterone Caused by Oxidative Stress and Aging

It has been known that adrenal corticoid is secreted markedly in neurodegenerative disease including Alzheimers disease during aging.The cause of this phenomenon is still unclear.Since Alzheimers dise

会议

Circulating Adiponectin Is Not Related to Serum MMP-9,TIMP,Walking Performance or Arterial Stiffness

Background:Obesity is associated with unfavorable changes in adipokine expressions,which might participate in insulin resistance and atherogenesis,and interact with matrix metalloproteinases in the pr

会议

Prevalence of Diabetes and Metabolic Syndrome of the Community-Dwelling Elderly Peoples in East and

Purpose:Metabolic syndrome is called " Deadly Quartet" and consists of central obesity,diabetes (DM),hypertension,lipid abnormality.As population-based epidemiological data of the syndrome are rare,th

会议

Metabolic syndromeDiabetesLaosThilandJapan

Reversal of Apoptotic Resistance by Lycium Barbarum Glycopeptide 3 in Aged T Cells

Objective:To study whether lycium barbarum glycopeptide 3 (LBGP3) can affect T cell apoptosis from the aged mice.Methods:LBGP3 was purified with DEAE cellulose and Sephadex columns.Apoptotic "sub-G1 p

会议

Histone Deacetylase Is Involved in yhe Inhibition of Tyrosine Hydroxylase Expression by α-Synuclein

与本文相关的学术论文