【摘 要】
：
A wide spectrum of metal based drugs offer some innovative results in chemotherapy.Titanium complexes exhibited cytostatic properties, mainly on colon tumor
【机 构】
：
Department of Biology University of Aveiro Portugal
【出 处】
：
BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
A wide spectrum of metal based drugs offer some innovative results in chemotherapy.Titanium complexes exhibited cytostatic properties, mainly on colon tumors.Highly substituted ansa-titanocene compounds have shown promising cytotoxic activity in a range of cancers, namely their potentiality for the treatment of advanced prostate cancer.Despite their efficacy as chemotherapeutic agents due to the possibility of coordination of some organic molecules to a metal centre which alters cellular metabolic pathways, some adverse effects were already described, namely a disruption within the permeability of the blood-testis barrier, a widely used toxicological marker on testis integrity.
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