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  5. Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery

Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery

来源 :第五届中国小核酸技术与应用学术会议 | 被引量 : 0次 | 上传用户：awubang
【摘 要】
：
　　Due to their biodegradable character,polyesters such as polycaprolactone(PCL),poly(D,L-lactide)(PDLLA),and polylactic-co-glycolic acid(PLGA)were widely used
【作 者】
：
Qiang Cheng Shangcong Han Anjie Dong Zicai Liang 
【机 构】
：
LaboratoryofNucleicAcidTechnology,InstituteofMolecularMedicine,PekingUniversity,Beijing100871,ChinaD
【出 处】
：
第五届中国小核酸技术与应用学术会议
【发表日期】
：
2015年9期
【关键词】
：
siRNA delivery PDMAEMA nanoparticle polyester endocytosis mechanism 
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论文部分内容阅读
　　Due to their biodegradable character,polyesters such as polycaprolactone(PCL),poly(D,L-lactide)(PDLLA),and polylactic-co-glycolic acid(PLGA)were widely used as the hydrophobic cores of amphiphilic cationic nanoparticles(NPs)for siRNA delivery.However,fewer researches focused on facilitating siRNA delivery by adjusting the polyester composition of these nanoparticles.
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