1-氯-3-丁烯-2-酮与脱氧鸟嘌呤核苷反应产物的结构鉴定

来源 :中国毒理学会第六届全国毒理学大会 | 被引量 : 0次 | 上传用户：ahyiahyi

【摘要】

：

1-氯-3-丁烯-2-酮(CBO)是1,3-丁二烯的一种代谢产物.丁二烯是一种致癌性环境污染物,主要环境来源为汽车尾气以及香烟烟雾等.丁二烯致癌性由其代谢物引起.它产生多种代谢物,如3,4-环氧-1-丁烯、1,2,3,4-双环氧丁烷和3,4-环氧-1,2-丁二醇等.CBO是最近新发现的一种代谢物.我们研究了CBO以及其前体1-氯-2-羟基-3-丁烯(CHB)的细胞毒性、遗传毒性和致突变性,发现CH

【作者】

：

张新宇李艳

【机构】

：

上海大学环境与化学工程学院,上海200444

【出处】

：

中国毒理学会第六届全国毒理学大会

【发表日期】

：

2013年7期

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1-氯-3-丁烯-2-酮与脱氧鸟嘌呤核苷反应产物的结构鉴定

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