【摘 要】
：
Arachidonic acids are converted to eicosanoid mediators by the distinct enzyme systems:cyclooxygenase, lipoxygenase and cytochrome P450 (CYP) monooxygenase path
【机 构】
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DepartmentofInternalMedicineandtheInstituteofHypertension,TongjiHospital,TongjiMedicalCollegeofHuazh
【出 处】
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2013 Shanghai Symposium on Polyunsaturated Fatty Acids and M
论文部分内容阅读
Arachidonic acids are converted to eicosanoid mediators by the distinct enzyme systems:cyclooxygenase, lipoxygenase and cytochrome P450 (CYP) monooxygenase pathways (ω/ω-1-hydroxylases and epoxygenases).CYP2J2, CYP2C8 and CYP2C9 are the predominant epoxygenase isoforms abundantly expressed in the endothelium, myocardium, and kidney in human.The primary epoxidation products by epoxygenases are four regioisomers of cis-epoxyeicosatrienoic acids (EETs):5,6-, 8,9-, 11,12-, and 14,15-EETs.
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