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Inflammatory pain belongs to the Traditional Chinese Medicine category of "Bizheng",whichwas caused by various inflammatory diseases including rheumtic arthritic,rheumatoid arthritis,osteoarthritis,fibrous tissue inflammation and so on.Electroacupuncture(EA) has great clinical curativeeffect on inflammatory pain without any side effect.However,the neuro-immune mechanism of EAtreating inflammatory pain has not been clarified completely.Inflammasome is the major pathway bywhich IL-1β and IL-18 mature and secreted.Inflammasome activation has been confirmed to participatein the pathophysiology of a variety of immune-related diseases.In our study,we attempted to investigatewhether activation of NLRP3 inflammasome is involved in Complete Freunds adjuvant (CFA)-inducedinflammatory pain,and whether the analgesic and anti-inflammatory effects of EA is through inhibitingthe activation of NLRP3 inflammasome,and further explore the mechanism of EA inhibiting activation ofthe NLRP3 inflammasome.