Deubiquitinase OTUD3 Regulates PTEN Stability and Suppresses Tumorigenesis

来源 :北京细胞生物学会2015年学术大会 | 被引量 : 0次 | 上传用户:echo_seaman
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PTEN is one of the most frequently mutated tumor suppressors and reduction in PTEN protein stability also plays a role in tumorigenesis.Although several ubiquitin ligases for PTEN have been identified, the deubiquitinase for de-polyubiquitination and stabilization of PTEN is less defined.
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