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Purpose:Neuroimagingstudiesofrelapsing-remittingmultiplesclerosis(RRMS)havefoundstructuraldisconnectionandlargescale neuralnetworkdysfunction.However,fewstudieshaveexploredthelocalbrainactivityofRRMSpatientsintheresting state.Methods:Inthisstudy,regionalhomogeneity(ReHo)andresting-statefunctionalconnectivity(FC)wereusedtoinvestigate intra-andinter-regionalsynchronizedactivityin22patientswithRRMSand22matchedhealthycontrols(HCs).