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Objectives To investigate the effect of telmisartan (telmi) on blood pressure, LV morphology, plasma angiotensin Ⅱ, expression of preproET-1 and ET-1 in left ventricular hypertrophy (LVH) of SHR.Methods Twenty Wistar-Kyoto (WKY) and twenty SHR were randomised to WKY + Vehicle (n =10), SHR + Vehicle (n =10), SHR + telmi (30mg/kg·d, n =10), WKY + telmi (n =10)groups.