Transradial vascular access provides several advantages with respect to transfcmoral access in terms of patients comfort, nurse workload, early patient mobilization and, most importantly, vascular access complications.A bulk of evidence demonstrates a tight relationship between vascular access site-related bleedings and short-as well as long term patient outcome.When performed by experienced operators, transradial technique reduces vascular access site-related bleedings by 70% with respect to transfemoral access without a significant trade-off in terms of feasibility or procedural success, even in the clinical setting of primary angioplasty in patients with ST-segment elevation myocardial infarction.