【摘 要】
：
This study aimed to investigate the possible mechanism of Salvia miltiorrhiza liposome (SalmL) to alleviate the pulmonary fibrosis induced by silica in vivo
【机 构】
：
SchoolofPublicHealth,CapitalMedicalUniversity,Beijing100069,ChinaBeijingKeyLaboratoryofEnvironmental
【出 处】
：
首都医科大学公共卫生学院第五届学术年会
论文部分内容阅读
This study aimed to investigate the possible mechanism of Salvia miltiorrhiza liposome (SalmL) to alleviate the pulmonary fibrosis induced by silica in vivo, in which thioredoxin reductase (TR) may play the role as an antioxidant enzyme.Rats were randomly divided into saline control group, silica group and SalmL preventive treatment group for 7, 15, 30, or 60 days consecutive experiment.Our results demonstrated silica could significantly decrease the expression of TR, resulting in the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) during the early period.Content of lung hydroxyproline and histopathological results showed significant fibrosis development.However, in SalmL group, the expression of TR was much higher than silica treated rats and ROS accumulation was less.Furthermore, histopathological examination revealed fibrosis alleviation.In conclusion, SalmL could restore TR expression decreased by silica to exert its inherent antioxidative function and alleviate the processing of pulmonary fibrosis induced by silica.
其他文献
慢性咳嗽是呼吸内科门诊常见的患者就诊原因.由于慢性咳嗽涉及的病因较为复杂,常常被误诊和误治.近年国内外都有慢性咳嗽的诊治指南发表,指导慢性咳嗽的诊治.慢性咳嗽的病因
慢性咳嗽的常见病因主要为支气管哮喘(咳嗽变异型哮喘)、嗜酸细胞性支气管炎、胃食管反流性疾病、鼻后滴流综合征(PNDs)及变应性咳嗽,这些病因占慢性咳嗽的70-95％.除了慢性咳
心因性咳嗽(Psychogenic cough)也称为心理性咳嗽,国外也有学者认为习惯性咳嗽(Habit cough)这个名称更为合适,后者为更广义的名称.各种文献关于习惯性咳嗽和心因性咳嗽的诊
Cough Variant Asthma(CVA)Irwin等1979年首次报道Potential Asthma Zhong Nanshan等1992年首次报道"隐匿性哮喘"概念在16年后仍然被国际主流医学杂志《柳叶刀》引用,指出"强
IPF患者持续性干咳的确切机制尚未明了，咳嗽敏感性增强、感觉神经元的功能性上调与咳嗽抑制神经损伤、外源性吸入物刺激、肺组织机械形变可能促使IPF患者产生慢性持续性干咳。
顽固性咳嗽，切忌见咳止咳。要注意引起咳嗽加剧的诱因，对于因寒冷咳剧者，应温肺，对于劳累致咳者，应补益肺肾，对于因情志不畅导致的咳嗽应治肝，或缓肝，或抑肝;咳嗽久治不愈，还需要注意
Background As highly productive as genomic information is, it is necessary to gauge or quantify the amount of information that reaches the lay public for th
β-amyloid-induced inflammation has been implicated in the early pathologic events in neurodegenerative diseases.The anti-inflammation potential of genistei
In Beijing, China, varicella vaccination had resulted in a dramatic decline in varicella morbidity and mortality since the 1-dose vaccination program was fi
判断咳嗽敏感性可以由咳嗽激发试验完成，通过给予特定刺激，诱发机体产生咳嗽，根据刺激因素的强度(如剂量、浓度等)及咳嗽情况，从而判断咳嗽敏感性。上世纪50年代起，学者应用柠檬酸