【摘 要】
：
Adenosine 5-triphosphate (ATP) was first discovered to be a transmitter at some autonomic neuroeffector junctions (Burnstock, 1972).Extracellular nucleotides were later shown to have actions in severa
【机 构】
：
University of Manchester, UK
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
论文部分内容阅读
Adenosine 5-triphosphate (ATP) was first discovered to be a transmitter at some autonomic neuroeffector junctions (Burnstock, 1972).Extracellular nucleotides were later shown to have actions in several tissues, including mast cells, macrophages and platelets.P2X and P2Y receptors were distinguished on the basis of agonist selectivity (Burnstock & Kennedy, 1985).Cloning of these receptor cDNAs showed a much more extensive distribution of these proteins and their RNAs: for example, P2X receptors on primary afferent nerves are now known to play roles in taste, sensation from hollow viscera, and inflammatory pain (North, 2002;Surprenant & North, 2009).
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