【摘 要】
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Aurora kinases play crucial role in cell division by the orchestration of pivotal mitotic events.Over-expression of these serine/threonine kinases have been noted in a variety of solid tumors(viz.colo
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
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Aurora kinases play crucial role in cell division by the orchestration of pivotal mitotic events.Over-expression of these serine/threonine kinases have been noted in a variety of solid tumors(viz.colon,breast,ovarian,gastric and pancreatic tumors) and haematological malignancies such as acute myelogenous leukaemia.Small molecule inhibitors of aurora kinases result in aberrant endoreduplication and apoptosis illuminating their significance as an attractive target for the discovery of novel anticancer agents.In our ongoing research endeavour to identify potent anticancer agents with indolin-2-one core,a new class of compounds with acylurea linker were rationally designed by applying the concept of bioisosterism.
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