【摘 要】
：
Aim: Tolerogenic dendritic cells (DCs) are well-known to show an immunosuppressive function.In this study, we determine the therapeutic effects and potential mechanisms of transferred bone marrow (BM)
【机 构】
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Institute of Clinical Pharmacology, Anhui Medical University, key Laboratory of Antiinflammatory and
【出 处】
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The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会)
论文部分内容阅读
Aim: Tolerogenic dendritic cells (DCs) are well-known to show an immunosuppressive function.In this study, we determine the therapeutic effects and potential mechanisms of transferred bone marrow (BM) CDllb+ F4/80+ DCs on collagen-induced arthritis (CIA) in the model mice.Methods: Murine BM CD11b+ F4/80+ DCs were generated under the stimulation of GM-CSF and IL-4 and then transferred to CIA mice by three intravenous injections.The joint and spleen histopathology was evaluated thereafter.The effects of transferred DCs on T lymphocytes were analyzed by determining proliferation capacity,numbers/percentages of Treg and Thl7 subsets, cytokine production, and expressions of Foxp3, Helios and RORγt.
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