This study aims to identify the miRNA involving in the regulation of TLR2 expression and signaling of COPD AMs in vivo and in vitro.By smoke inhalations,COPD rats were successfully prepared.Among 11 u
目的 探讨博来霉素(Bleomycin,BLM)诱导的小鼠肺纤维化中,自噬诱导剂rapamycin和自噬阻断剂3-Methyladenine对肺纤维化的影响.方法 6-8周C57小鼠随机分为4组,每组12只,分别为对照组、BLM组、BLM+rapamycin(rapa)组,BLM+ 3-Methyladenine (3-MA)组.BLM(0.5mg/kg,100ul)单次气管内滴注造模,并于造模次
Background: Pulmonary fibrosis is a progressive disease with poor prognosis and treatment.It is characterized by lung fibroblast actvation and extracellular matrix(ECM) deposition,.Heat shock protein
背景及目的 人胸腺基质淋巴细胞生成素(TSLP)作为Th2炎症关键介质,近年研究发现其两种亚型：长链TSLP(long TSLP,1TSLP)和短链TSLP(short TSLP,shTSLP)作用完全不同.1TSLP主要促进炎症反应.而shTSLP则发挥了抗炎抗菌作用.目前TSLP亚型在哮喘中的作用尚未见报道.
Objective: The aim of the present study is to investigate the protective effects of ghrelin in LPS-induced apoptosis of human alveolar epithelial A549 cells and the possible molecular mechanisms.Metho
Kleene-Levin syndrome (KLS) is a rare disorder primarily occur in adolescents,is characterized by intermittent episodes of hypersomnolence,cognitive and behavioral disturbances and hyperphagia.Our cas
目的 探究香烟烟雾提取物(CSE)刺激人气道上皮细胞(HBE)分泌膜联蛋白A1(annexinAl)的机制及其在慢性阻塞性肺疾病(COPD)的气道重塑中的作用.方法 收集正常组(15例)、稳定期COPD组(22例)、AECOPD组(10例)血标本、痰标本、肺功能等相关资料.ELISA检测血清、痰上清的IL-8、annexinA1水平.将肺功能和血清、痰上清的IL-8、anexinA1水平进行相关性