Background: Pulmonary fibrosis is a progressive disease with poor prognosis and treatment.It is characterized by lung fibroblast actvation and extracellular matrix(ECM) deposition,.Heat shock protein 90(Hsp90) plays a significant role in multiple cellular process,especially extracellular heat shock protein 90 alpha(eHsp90 a) can promotes wound healing induced by fibroblast actvation and migration.