Objective: Social support is nearly routinely included in the psychosocial evaluation of patients involved in heart transplant programs.However, its role in this population has been insufficiently explored.We examined the associations between perceived social support and dimensions of psychological well-being at long-term after cardiac transplantation.Methods: Sixty six patients transplanted from 10.2 ± 3.3 years completed the Interpersonal Support Evaluation List (ISEL, by S.Cohen, R.Mermelstein, T.Kamarck & H.M.Hoberman) (total level and four functions of social support:appraisal, belonging, tangible, self-esteem) and C.Ryffs Psychological Well-Being Scales (PWB) (autonomy,environmental mastery, personal growth, purpose in life, positive relations, self-acceptance).Results: All the ISEL scores were positively related to PWB environmental mastery, positive relations and purpose in life (all p<0.01).PWB autonomy was higher in patients more satisfied for total social support (p<0.01) and for ISEL dimensions regarding appraisal, belonging and tangible support (all p<0.05).Personal growth was positively associated with ISEL appraisal (p<0.01), self-esteem (p<0.05) and total social support (p<0.01).All the dimensions of support, with the exception of ISEL tangible support, significantly correlated with better self-acceptance (all p<0.05).Conclusions: We found social support and psychological well-being strictly associated each other.Yet, the cross sectional nature of our data did not let us determine the direction of this relationship.Social support may play a protective role against psychological distress and promote positive functioning.It can also be inferred that diminished psychological well-being worsens patients satisfaction for their interpersonal resources.Future studies should evaluate whether the provision ofpsychotherapeutic strategies for the amelioration of psychological functioning, such as the Well-Being Therapy, may also result in a better social support perception.