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Purpose: To evaluate the hemodynamics and vasoreactivity in the posterior cerebral artery (PCA) in patients with primary open-angle glaucoma (POAG).Design: Case-control study.Participants: Thirteen POAG patients (age range,40-60 years) with marked visual ?eld loss (mean deviation[MD],<-6 dB);a preserved,mostly normal,central visual ?eld of at least 50;and best-corrected visual acuity of at least 20/40 formed the study group.