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Human immunodeficiency virus type 1(HIV-1)is the pathogen of human acquired immunodeficiency syndrome(AIDS).Having no counterpart in the mammalian body,HIV-1 integrase is an attractive enzyme to target for treating AIDS with small molecules.This enzyme catalyzes two steps,3 processing(3P)step and strand transfer(ST),and compounds which could block-up any one of these two steps show the inhibitory activity to the HIV-1 integrase.