目的：To exhibit the current status of treatment for alteplase(rt-PA)intravenous thrombolysis for acute ischemic stroke patients in Henan Provinval Peoples Hospital,and clarify the relevant factors affecting patientscompliance of intravenous thrombolysis.方法：The acute ischemic stroke patients in Department of Emergency,Henan Provinval Peoples Hospital from January 2014 to December 2015 were recruted prospectively.After contraindications were excluded,the patients were divided into two groups,intravenous thrombolysis group(ITG)and non-intravenous thrombolysis group(NTG).Receiver operating characteristic curve(ROC)was used to determine the optimal cutoff NIHSS score of patientsdecision on thrombolysis therapy.结 果：There were 230 patients of acute ischemic stroke of Department of Emergency,Henan Provinval Peoples Hospital in the two years mentioned above totally.Among them,189 were chosen as eligible patients,and 33 patients refused intravenous thrombolysis(NTG)whereas 156 patients received intravenous thrombolysis(ITG).The intravenous thrombolysis rate of eligible ischemic stroke patients in Henan Provinval Peoples Hospital reached to 67.8％excluding contraindications,The results of the single-factor analysis for the patients from the two groups displayed that the factors including age,baseline NIHSS score,limb weakness,hemiplegic paralysis,as well as dysphasia were significantly different between the two groups(t=2.578,P=0.047；U=157.221,P=0.000；X2=26.702,P=0.000；X2=9.069,P=0.003；X2=7.381,P=0.007；X2=28.636,P=0.000).The ROC analysis demonstrated the relationship between the baseline NIHSS score and the receiving of intravenous thrombolysis of the patients.When NIHSS score＜7,patients tended to refuse the treatment of intravenous thrombolysis(sensitivity 0.87,specificity 0.82).In the comparison of the patients received intravenous thrombolysis,intracranial hemorrhage rate,hospitalization mortality rate and 3-month mortality rate between the patients with baseline NIHSS score≥7 or score＜7 did not show significant different(1.9％vs 3.9％,P= 0.662；1.9％vs 7.8％,P=0.168 and 3.8％vs 11.7％,P=0.142 respectively),However a higher rate of favourable prognosis(3-month modified Rankin Scale score≤1)was observed(75.5％vs 41.7％,P=0.000).结论：Factors such as age,baseline NIHSS score,limb weakness,hemiplegic paralysis,dysphasia,as well as dizziness are supposed to be associated with patientscompliance of intravenous thrombolysis.