Synthesis of Functionalized Isoquinolin-1(2H)-ones via Copper-Catalyzed sp3 C-H Arylation of Ketones

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户：assasad

【摘要】

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【作者】

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Xuebin Zhu Chengjian Zhu

【机构】

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School of Chemistry and Chemical Engineering,State Key Laboratory of Coordination Chemistry,Nanjing

【出处】

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The 24th International Society of Heterocyclic Chemistry Con

【发表日期】

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2013年4期

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A novel and efficient copper-catalyzed annulation of ketones with 2-halobenzamides has been accomplished.This reaction featuring sp3 C-H arylation and C-N bond formation processes provides a concise access to isoquinolin-1(2H)-ones from simple and readily available starting materials.The method could tolerate various functional groups in the substrates.

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Synthesis of Functionalized Isoquinolin-1(2H)-ones via Copper-Catalyzed sp3 C-H Arylation of Ketones

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