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  5. The protective action of ketanserin against LPS-induced shock in mice is mediated by inhibiting iNOS

The protective action of ketanserin against LPS-induced shock in mice is mediated by inhibiting iNOS

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：wujun33
【摘 要】
：
Aim: Nitric oxide (NO) plays an important role in the pathogenesis of endotoxic shock.The present work tested the hypothesis that ketanserin could attenuate endotoxic shock by inhibiting the expressio
【作 者】
：
Chong LIU Xin ZHANG Ju-xiang ZHOU Wei WEI Dian-hua Liu Gu-fang ZHANG Ping KE Guo-jun CAI Ding-feng SU 
【机 构】
：
Department of Pharmacology,Second Military Medical University,Shanghai 200433,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
ketanserin endotoxic shock inducible nitric oxide synthase nitric oxide 
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Aim: Nitric oxide (NO) plays an important role in the pathogenesis of endotoxic shock.The present work tested the hypothesis that ketanserin could attenuate endotoxic shock by inhibiting the expression of iNOS.Methods and Results: The results demonstrated that ketanserin could inhibit iNOS expression in the heart,lungs, liver and kidneys and nitrate production in the serum upon endotoxic shock in mice.
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