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红花是一类广泛用于心脑血管及妇科疾病治疗的传统中药,主要化学成分为黄酮类、多糖类、脂肪酸类、生物碱类等。其中黄酮类化合物是红花发挥治疗作用的主要成分,其主要药理活性包括抗氧化、抗凝血、抗炎及神经保护作用等。我们的实验研究表明,质量标准化的红花黄酮类提取物能够改善MPTP、6-OHDA、鱼藤酮诱导的PD动物模型的行为学、病理学、脑微环境等的改变。其指标成分红花黄色素B和山奈酚-3-O-芸香糖苷,够抑制H2O2、鱼藤酮诱导的细胞损伤,本文就质量标准化的红花黄酮类提取物的抗帕金森病的药效学及其机制进行较为系统的综述,以期为进一步临床应用提供科学依据。
Safflower is a kind of traditional Chinese medicine widely used in the treatment of cardiovascular and gynecological diseases. Its main chemical components are flavonoids, polysaccharides, fatty acids and alkaloids. Among them, flavonoids are the main ingredients of safflower to play a therapeutic role. Its main pharmacological activities include anti-oxidation, anticoagulant, anti-inflammation and neuroprotection. Our experimental studies show that the quality-standardized safflower flavonoids can improve the behavioral, pathological and cerebral microenvironment changes of MPTP, 6-OHDA and rotenone-induced PD animal models. Its indicator components safflower yellow pigment B and kaempferol -3-O-rutin glycosides, enough to inhibit H2O2, rotenone-induced cell damage, the quality of standardized safflower flavonoids anti-Parkinson’s disease pharmacodynamics and The mechanism of a more systematic review, with a view to provide a scientific basis for further clinical application.