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  5. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP

Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP

来源 :2016年第一届中国微循环周(中国病理生理学会微循环专业委员会全体会议、世界中医药学会联合会气血专业委员会全体会议、中国 | 被引量 : 0次 | 上传用户：hongyun64
【摘 要】
：
Ruscogenin,an important steroid sapogenin derived from Ophiopogon japonicus,has been shown to inhibit cerebral ischemic injury.However,its potential molecular action on blood-brain barrier(BBB)dysfunc
【作 者】
：
Guo-Sheng Cao Nan Jiang Yang Hu Yuanyuan Zhang Guangyun Wang Mingzhu Yin Xiaonan Ma Kecheng Zhou Jin Qi Boyang Yu Junping Kou 
【机 构】
：
Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research,Departm
【出 处】
：
2016年第一届中国微循环周(中国病理生理学会微循环专业委员会全体会议、世界中医药学会联合会气血专业委员会全体会议、中国
【发表日期】
：
2016年5期
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论文部分内容阅读
　　Ruscogenin,an important steroid sapogenin derived from Ophiopogon japonicus,has been shown to inhibit cerebral ischemic injury.However,its potential molecular action on blood-brain barrier(BBB)dysfunction after stroke remains unclear.This study aimed to investigate the effects of ruscogenin on BBB dysfunction and the underlying mechanisms in middle cerebral artery occlusion/reperfusion(MCAO/R)-injured mice and oxygen–glucose deprivation/reoxygenation(OGD/R)-injured mouse brain microvascular endothelial cells(bEnd.3).
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