【摘 要】
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Diffuse large B-cell lymphoma (DLBCL) is one of the most common forms of adult non-Hodgkin lymphoma (NHL).The addition of rituximab to standard CHOP chemotherapy regimens results in an improved overal
【机 构】
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University of Nebraska Medical Center,Omaha,NE,USA
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Diffuse large B-cell lymphoma (DLBCL) is one of the most common forms of adult non-Hodgkin lymphoma (NHL).The addition of rituximab to standard CHOP chemotherapy regimens results in an improved overall survival rate of 10% to15%.A substantial number of patients still die of the disease,highlighting the need for improved DLBCL prognostication and better therapy.DLBCL is a biologically and clinically heterogeneous disease that can be divided into two main subgroups: germinal center B-cell-like (GCB) DLBCL and activated B-cell-like (ABC) DLBCL.GCB-DLCBL represents transformed GC centroblasts that highly express the GC master regulator BCL6 and lack features of B-cell activation.
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