The ability of polyamine amides to bind to glutamate receptors has made them useful in studying cancer propagation [1].In order to harness this ability,4-hydroxyphenylacetyl spermine was conjugated onto the mesoporous silica nanoparticles (MSNPs) for delivery into cancerous cellsby targeting the glutamate receptors on the cell surface [2].The MSNPs were synthesized via a condensation reaction,which was followed by a "click" reaction to couple the alkyne functionalized 4-hydroxyphenylacetyl spermine onto the MSNP surface (Fig.1).