2. 您的位置
3. 首页
4. 会议论文
5. Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice v

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice v

来源 :The 2016 International Conference on Lipid Metabolism and Bi | 被引量 : 0次 | 上传用户：sandland

【摘 要】

：

TBC1D1 is a RabGTPase activating protein that is phosphorylated on Ser231 by the AMP-activated protein kinase (AMPK) in response to intracellular energy stress.However,the in vivo role and importance

【作 者】

：

Liang Chen Qiaoli Chen Bingxian Xie Chao Quan Yang Sheng Shuilian Zhou Kei Sakamoto Carol MacKintosh Hong Yu Wang Shuai Chen 

【机 构】

：

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Dise

【出 处】

：

The 2016 International Conference on Lipid Metabolism and Bi

【发表日期】

：

2016年11期

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　TBC1D1 is a RabGTPase activating protein that is phosphorylated on Ser231 by the AMP-activated protein kinase (AMPK) in response to intracellular energy stress.However,the in vivo role and importance of this phosphorylation event remains unknown.

其他文献

Potentiating the antitumor response of CD8+ T cells by modulating cholesterol metabolism

CD8+ T cells have a central role in antitumor immunity,but their activity is suppressed in the tumor microenvironment.Reactivating the cytotoxicity of CD8+ T cells is of great clinical interest in can

会议

Adrenomedullin 2 Inhibits Adipocyte Antigen Presentation Function in High-Fat Diet Induced Adipose I

The dysfunction of adipose tissue plays an important role in metabolic disorders.Adipose inflammation is involved in the pathogenesis of diet-induced adipose dysfunction.Adipose innate immunological r

会议

Alleviation of ER stress and its associated insulin resistanceby fatty acid chaperons

Insulin resistance is a hallmark in the development of type 2 diabetes mellitus (T2DM),which is associated with obesity.A considerable number of recentstudies have pointed out a critical role of endop

会议

AMPK signaling pathway and activation of SREBP1 in the promoted hepatic lipid accumulation by SSRI a

Fluoxetine (FLX),a typical drug belonging to the category of selective serotonin reuptake inhibitors (SSRI),is the most widely prescribed psychoactive drug in the treatment of depression and other moo

会议

fluoxetinelipid accumulationhepatocytesAMP-activated protein kinaseSREBP

A SANT-like domain-containing protein regulates lipid droplet size

Lipid droplets (LDs) are the organelles responsible for lipids storage.The sizes of LDs vary greatly under different physiological conditions.Comprehensive studies show that LDs size is important for

会议

ApoA-Ⅳ modulates diet-induced obesityand metabolic disorders

Background and objective: Obesity-associated metabolic inflammation,which promotes insulin resistance,is the pathogenesis of obesity-related metabolic disorders.ApoA-Ⅳ produced by enterocytes is a maj

会议

Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit

Upon adaption of skeletal muscle tophysiological and pathophysiological stimuli,muscle fiber type and mitochondrial function are coordinately regulated.Recent studies have identified pathways involved

会议

Quantitative Control in Endoplasmic Reticulum Exiting of Lipid Cargos Specified by SAR1B

Proteins and lipids are two major classes of transport cargos servingspecific physiological functions.Howthese distinct biomolecules are differentiallysorted through the secretory pathway,however,rema

会议

Cytochrome b5 oxidoreductase HPO-19 and cytochrome b5 CYTB-5.1 are required for biosynthesis of poly

Polyunsaturated fatty acids (PUFAs) are essential components for cell membrane as well as many cellular and physiological processes.In mammals,PUFAs are synthesized via an aerobic process starting fro

会议

NADH cytochrome b5 reductase HPO-19/T05H4.4cytochrome b5 CYT-5.1fatty acid des

DHI improves Diet-induced Obesity and alleviates Insulin Resistance by Suppressing SREBP Activation

Sterol regulatory element-binding proteins (SREBPs) are most important transcription factors which activate the expression of target genes involved in biosynthesis of fatty acid,triglyceride and chole

会议