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  5. Procaspase-3 activator PAC-1 and YCL0426 induce hypoxia reaction and DNA damage in tumor cells

Procaspase-3 activator PAC-1 and YCL0426 induce hypoxia reaction and DNA damage in tumor cells

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：ADAM129XU
【摘 要】
：
Aim: PAC-1 is the first small molecular compound identified to induce apoptosis by direct activation of procaspase-3 into caspase-3, the main executor of apoptosis.YCL-0426 is a potent procaspase-3 ac
【作 者】
：
Fei-fei LI Long LONG Wei LI Chang-qi ZHAO Li-li WANG 
【机 构】
：
Key Laboratory of Cell Proliferation and Regulation Biology (Beijing Normal University), Ministry of
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
apoptosis procaspase-3 Rad51 foci Hif-1α high content analysis 
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Aim: PAC-1 is the first small molecular compound identified to induce apoptosis by direct activation of procaspase-3 into caspase-3, the main executor of apoptosis.YCL-0426 is a potent procaspase-3 activating compound synthesized in our lab.In this study, the antitumor mechanism and the impact to other signal pathways of PAC-1 and YCL0426 were investigated.
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