【摘 要】
：
Chalcones,which are abundant in plants as a class of flavonoids,are confirmed to possess a diverse array of pharmacological activities and considered as a p
【机 构】
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New Drug Research & Development Center School of Pharmceutical Science,Zhengzhou Univercity,Ke Xue D
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Chalcones,which are abundant in plants as a class of flavonoids,are confirmed to possess a diverse array of pharmacological activities and considered as a promising template for drug design,and especially as antitumor drugs.According to the structure-activity relationship,many active compounds have been synthesized.Through researching a series of references about structure-activity relationship,we speculate that brominated chalcones have very good antitumor activity,and more than 20 new compounds have been synthesized.Firstly,directed regioselectivity of bromination of ketones with NBS,and then through Claisen-Schmidt reaction get target compounds.Activity test is under way.All the compounds were characterized by means of IR,1H-NMR and 13C-NMR spectral data.
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