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In the cancer tissue, except for neoplastic cells, there are different kinds of stromal cells, such as fibroblasts, endothelial cells as well as hematopoietic pro-inflammatory cells.Fibroblasts, which produce pro-inflammatory cytokines, chemokines and extracellular matrix and directly or indirectly influence the death or survival of cancer cells during cancer development and cancer therapy, are the main cellular component of the tumor stroma.