【摘 要】
：
Breast cancer remains a prevalent disease worldwide.Despite a significant progress in early detection,many cancer patients at primary diagnosis experience r
【机 构】
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McGillUniversityCanada
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
Breast cancer remains a prevalent disease worldwide.Despite a significant progress in early detection,many cancer patients at primary diagnosis experience recurrence of the cancer.Of these scenarios,development of metastases is the most life threatening and ultimately incurable with the best therapies available to date.A crucial early event by which cancer cells switch from localized to invasive states is initiated by the acquisition of autonomous motile and invasive properties.This process is tightly regulated by multiple focal adhesion and cytoskeleton molecules,including integrins,Src kinases,Fak,paxillin,Cas,talin,vinculin,and myosins.
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