Vitamin B3 Activation of the Capsaicin Receptor TRPV1 May Serve as A Potential Mechanism for Cutaneo

来源 :The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 | 被引量 : 0次 | 上传用户：ping_ge

【摘要】

：

Vitamin B3 is widely used to treat dyslipidemias and reduce blood cholesterol.However, a substantial fraction of patients discontinue this safe and beneficial t

【作者】

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Jie Zheng

【机构】

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DepartmentofPhysiologyandMembraneBiology,UCDavisSchoolofMedicine

【出处】

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The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功

【发表日期】

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2014年7期

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Vitamin B3 is widely used to treat dyslipidemias and reduce blood cholesterol.However, a substantial fraction of patients discontinue this safe and beneficial treatment because of a strong side effect of cutaneous vasodilation, commonly called flushing.We recently discovered that VB3 may cause flushing partially by activating TRPV1, a Ca2+-permeable polymodal cellular sensor that mediates the flushing response upon eating spicy food.

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Vitamin B3 Activation of the Capsaicin Receptor TRPV1 May Serve as A Potential Mechanism for Cutaneo

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