染色质重塑蛋白BRG1在DNA双链断裂损伤修复中的作用及机制研究

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：lijizhong520

【摘要】

：

DNA双链断裂(DSBs)是一种严重的DNA损伤类型.为了维持基因组的稳定性，真核生物的DNA通过与组蛋白结合进化出更为复杂紧密的染色质结构.然而这种致密的结构对于DNA的转录，复制和修复等代谢过程是一个巨大的障碍.BRG1是染色质重塑复合物SWI/SNF的核心亚基，它具有ATP水解酶活性.已有研究发现BRG1与肿瘤发生和基因组不稳定性具有重要联系.

【作者】

：

齐文靖王若曦陈红玉王晓琳肖婷 Istvan Boldogh 巴雪青汉丽萍曾宪录

【机构】

：

东北师范大学,吉林省长春市,130024,中国德克萨斯大学医学分校,德克萨斯州加尔维斯顿,775

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

DNA双链断裂损伤修复染色质重塑 BRG1 同源重组修复 RAD52

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染色质重塑蛋白BRG1在DNA双链断裂损伤修复中的作用及机制研究

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