【摘 要】
：
Background: Motivation: Containing about 22 nucleotides, a microRNA (abbrevi-ated miRNA) is a small non-coding RNA molecule, functioning in transcriptional and post-transcriptional regulation of gene
【机 构】
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广东省深圳市哈尔滨工业大学深圳研究生院计算机科学与技术学院,518055;广东省深圳市哈尔滨工业大学深圳研究生院网络环境智能计算重点实验室,518055
【出 处】
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第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
论文部分内容阅读
Background: Motivation: Containing about 22 nucleotides, a microRNA (abbrevi-ated miRNA) is a small non-coding RNA molecule, functioning in transcriptional and post-transcriptional regulation of gene expression.The human genome may encode over 1000 miRNAs.Albeit poorly characterized, miRNAs are widely deemed as important regulators of biological processes.Aberrant expression of miRNAs has been observed in many cancers and other disease states, indicating they are deeply implicated with these diseases, particularly in carcinogenesis.Therefore, it is important for both basic research and miRNA-based therapy to discriminate the real pre-miRNAs from the false ones (such as hairpin sequences with similar stem-loops).Particularly, with the avalanche of RNA sequences generated in the postgenomic age, it is highly desired to develop computational sequence-based methods in this regard.
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