Harnessing activity-based protein profiling to reveal the mechanism of nintedanib against pulmonary

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The benzofuroindoline is a core motif in many natural alkaloids.An important biosynthetic pathway for this molecular framework is oxidative [3+2]cycloaddition of phenols with indoles[1].
5-甲基胞嘧啶是一种常见的DNA 甲基化修饰,该修饰对多种生物学过程有至关重要的调控作用.5-甲基胞嘧啶在Tet 蛋白的催化作用下可以被逐步氧化为5-羟甲基胞嘧啶、5-醛基胞嘧啶及5-羧基胞嘧啶.
高能射线(辐照)具有高时空分辨率,高组织穿透力,在临床医疗中广泛用于癌症的治疗.如果能将辐照用于高毒副作用药物的可控释放1,将会给肿瘤治疗带来关键性的突破2.但辐照所引发的化学反应通常缺乏选择性.解决这个问题的关键是筛选出对辐照有选择性的化学基团.
Weed management has been a concern throughout the worlds history.Using herbicides is one of the most effective ways to manage weeds and preserve crop quality and yields.
顺铂是使用最广泛的金属抗癌药物,但在癌症治疗中存在耐药性,临床上克服顺铂耐药是与其它药物一起联合用药,然而,联合用药仍存在毒副作用及耐药性。[1]因此,需要新的治疗方法来提高治疗效率,减少毒副作用。光动力治疗具有非入侵性和可控性,光敏剂在光照下产生活性氧物种,造成癌细胞氧化损伤,导致细胞死亡。
肿瘤内血管既是肿瘤细胞氧和营养传输通道,同时也是肿瘤转移的渠道。早在1994 年美国抗癌协会就发现通过阻断肿瘤血管可以有效的抑制肿瘤生长同时阻止其转移。[1]过去十年中光动力治疗由于其创伤小、治疗效率而成为抗肿瘤研究中的热点。
Interferon gamma(IFN-γ)is an important cytokine,which regulate the transcription of immune related genes and coordinate the immune response of organisms.
Copper indium diselenide(CISe)quantum dots(QDs)are attractive as potential optoelectronic devices,since they have large absorption coefficients across abroad spectral range,size-and composition-tunabl
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