Design,Synthesis and in vitro Neuromuscular Blocking Activity of 3β/α-Pyrrolidino-16β-morpholino-5α-

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：lsssml1990

【摘要】

：

【作者】

：

Zhigang Rao Peng Liu Xianming Hu

【机构】

：

Wuhan University School of Pharmaceutical Sciences,Wuhan 430071

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　The neuromuscular blocking agents(NMBAs) are widely used in anesthesia as muscle relaxant.The steroid skeleton,decorated with two ammonium groups at proper positions,provides an excellent core for exploring potential NMBAs due to its rigidity.On the basis of the recent development on amino-steroidal neuromuscular blocking agents,we designed three new steroidal 3,16-bis-quaternary ammoniun salts.Starting from 16α-Br-5α-epaindrosterone,we got 6,7b and 7a after 5 steps(Scheme 1).

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Design,Synthesis and in vitro Neuromuscular Blocking Activity of 3β/α-Pyrrolidino-16β-morpholino-5α-

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