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Objective: Results from publications of Kangai injection+FOLFIRI strategy on colorectal cancer are not consistent.We aimed to determine whether the benefits of Kangai injection+FOLFIRI strategy outweigh the FOLFIRI strategy alone in patients with colorectal cancer.Methods: We conducted a meta-analysis investigating the synergistic antitumor effect and reducing side effect in trials of Kangai injection+FOLFIRI strategy in colorectal cancer.