【摘 要】
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LS is perhaps the most common hereditary, monogenic cancer syndrome.The frequency of gene carriers is 1 in 1000.The main features are autosomal dominant inh
【机 构】
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Professor in General Surgery Jyv(a)skyl(a) Central Hospital University of East Finland Finland
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LS is perhaps the most common hereditary, monogenic cancer syndrome.The frequency of gene carriers is 1 in 1000.The main features are autosomal dominant inheritance, increased risk for colorectal (CRC), endometrial, gastric, ovarian, urothelial, brain and some other cancers at young age.LS is caused by germline mutations in a MMR gene.Tumors from individuals with LS exhibit MSI (Microsatellite instability), which can be used for screening of LS if family history is not typical or available.
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