【摘 要】
：
In recent years,the discovery of nitric oxide(NO)as a signaling molecule in various physiological and pathological pathways has spurred research on the desi
【机 构】
：
Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry,Institute of Mole
【出 处】
：
2018中西部地区无机化学化工学术研讨会
论文部分内容阅读
In recent years,the discovery of nitric oxide(NO)as a signaling molecule in various physiological and pathological pathways has spurred research on the design of metal nitrosyl complexes with novel photo-induced reactivity and cellar biological activity [1–4].In this work,nitrosylruthenium complexes using 8-hydroxyquinoline derivatives and amino acids as ligands were synthesized,and their photodynamic reactions were investigated.The photochemical DNA cleavage of the complexes was also demonstrated,possibly due to photo-induced free radicals.The crystal structures were determinated by X-ray diffraction,the photo-induced NO-release were confirmed through spin trapping of the electron paramagnetic resonance spectroscopy(EPR),and the dynamic process of the NO dissociation upon photo irradiation was monitored using time-resolution and two-dimensional correlation infrared spectroscopy
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