【摘 要】
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Highly selective K+ channels play a key role in regulation of cellular excitability and electrolyte homeostasis.It was previously thought that ion selectivity o
【机 构】
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DepartmentofBiologicalSciencesandtheCenterforNeuroscienceResearch,UniversityatAlbany,StateUniversity
【出 处】
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The 4th International Ion Channel Conference(第四届国际离子通道会议)
论文部分内容阅读
Highly selective K+ channels play a key role in regulation of cellular excitability and electrolyte homeostasis.It was previously thought that ion selectivity of K+ channels,which is mainly determined by the selectivity filter, does not change in response to physiological stimuli.However, recent studies indicate that two-pore domain K+ (K2P) channels, the newest subfamily of K+ channels, change ion selectivity and permeability in response to physiological or pathophysiological stimuli,demonstrating a new mechanism that regulates cellular function.
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