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5. Enhanced anti-tumor efficacy by co-delivery of GDC-0449 with size-tunable polymeric SN38 nanoparticl

Enhanced anti-tumor efficacy by co-delivery of GDC-0449 with size-tunable polymeric SN38 nanoparticl

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：guobinlei

【摘 要】

：

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal human cancer with a poor prognosis and a 5-year survival rate of less than 7%.In recent years,the roles of fibroblasts in PDAC microenvironme

【作 者】

：

Liying Wang Quan Zhou Xiangrui Liu Zhuxian Zhou Jianbin Tang Youqing Shen 

【机 构】

：

Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Educ

【出 处】

：

Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

：

2016年11期

【关键词】

：

pancreatic cancer pancreatic stellate cells GDC-0449 SN-38 size-tunable nanopart 

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　　Pancreatic ductal adenocarcinoma (PDAC) is the most lethal human cancer with a poor prognosis and a 5-year survival rate of less than 7%.In recent years,the roles of fibroblasts in PDAC microenvironment become increasingly apparent.

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