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KCNQ2/3 potassium channels are the structural basis of M-current in nervous system, and have been known as a target to screening antiepileptic drugs.We have designed and synthesized a series of propanamide compounds;some of them have been shown to be able to activate KCNQ channels by using an automatic Rb+ efflux system for high-throughput screening.We studied the effects of C15 on KCNQ2/3 channels stably expressed in HEK293B cells using perforated whole-cell patch clamp technique, and our data showed that chemical compound C 15 has an obviously potent ability to open KCNQ2/3 channel.