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  5. One of propanamide derivatives C15 gained a potential ability to open KCNQ2/3 potassium channel

One of propanamide derivatives C15 gained a potential ability to open KCNQ2/3 potassium channel

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：wugenkuaizi
【摘 要】
：
KCNQ2/3 potassium channels are the structural basis of M-current in nervous system, and have been known as a target to screening antiepileptic drugs.We have designed and synthesized a series of propan
【作 者】
：
Qian Zhao Qingzhong Jia 
【机 构】
：
Department of Pharmacology, Hebei medical university, Shijiazhuang, China
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
Compound C15 KCNQ2/3 channel EC50 V1/2 
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KCNQ2/3 potassium channels are the structural basis of M-current in nervous system, and have been known as a target to screening antiepileptic drugs.We have designed and synthesized a series of propanamide compounds;some of them have been shown to be able to activate KCNQ channels by using an automatic Rb+ efflux system for high-throughput screening.We studied the effects of C15 on KCNQ2/3 channels stably expressed in HEK293B cells using perforated whole-cell patch clamp technique, and our data showed that chemical compound C 15 has an obviously potent ability to open KCNQ2/3 channel.
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