IDH1R132H mutation induces a less aggressive phenotype of glioma cells and affects the radiosensitiv

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户:q365709285
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Objective Gliomas are often found to contain mutations in the isocitrate dehydrogenase 1(IDH1)gene,and the most common type of mutation is the R132H mutation.
其他文献
Objective To investigate the expression and role of RPS15A in human breast cancer.In this study,we first evaluated the expression of RPS15A in human BC cell lines.
目的 Dickkopf相关蛋白1(DKK1)作为Wnt信号通路抑制剂是胃癌发生发展中重要的分子,既往研究证实DKK1的启动子甲基化是胃癌患者生存率低的独立危险因素。胃黏膜肠上皮化生是胃癌重要的癌前病变阶段,也是临床上重要的干预治疗时间窗,但目前肠上皮化生的发生机制未完全明确。
Objective Zinc-finger proteins(ZFPs)are the largest transcription factor family in mammals,involved in the regulation of multiple physiologic processes including cell differentiation,proliferation,apo
目的 肺腺癌(Lung adenocarcinoma,LAC)是肺癌中最常见的病理类型,深入解析LAC 发生、发展的机制对LAC 的治疗及预后评估具有重要的临床意义。线粒体丙酮酸载体1(MPC1)可将丙酮酸从胞质运输到线粒体内参与细胞能量代谢,在结直肠癌、前列腺癌、食管鳞状细胞癌等多种恶性肿瘤中异常表达,但其在NSCLC 中的表达及功能尚不清楚。
Objective The heterogeneity of acute myeloid leukemia(AML)plays an important role in the development of drug resistance.
Objective Aberrant activation of Wnt/β-catenin signaling pathway contributes to carcinogenesis of CRC,controlling lots of biological processes in colorectal cancer,including cell fate determination,ce
Objective Lung cancer is ranked as the worlds leading cause of cancer-related death,with poor prognosis that severely threatens human life.
目的 目的:本研究针对CD19 阳性的血液恶性肿瘤设计一种抗CD19 的CAR-T 细胞,建立安全有效的CAR-T 体外培养系统,检测其体内体外活性,为CAR-T 技术在血液恶性肿瘤中的临床研究及应用提供实验依据。
Objective In tumors,genetic heterogeneity reflects the complicated constitution of different cells(which could be referred as subclones).Under the selective pressure provided by tumor microenvironment
Objective Colorectal carcinoma(CRC)is the third most commonly diagnosed cancer in males and the second in females in the world,with approximately 1.3 million new cancer cases and over 0.6 million deat