Application of a UPLC-MS/MS method for the quantification of OM in rat tissue biodistribution after

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：zwf1979

【摘要】

：

　　Introduction: Oxymatrine (OM) is a kind of alkaloid extracted from a Chinese herb, which has been found to possess anti-hepatic fibrosis effect, but its ant

【作者】

：

JianhongYang[1]YanhuiHou[1]JianhaiChen[2]

【机构】

：

School of Pharmacy, Ningxia Medical University, No.1160 Shengli South Street, Yinchuan, 750004, Chin

【出处】

：

2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会

【发表日期】

：

2015年期

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　　Introduction: Oxymatrine (OM) is a kind of alkaloid extracted from a Chinese herb, which has been found to possess anti-hepatic fibrosis effect, but its anti-fibrotic potential may be limited due to poor distribution in liver and a risk of adverse effects.In this study, we developed a novel targeted drug delivery system based on OM-loaded polymersomes (PM) modified with the peptide RGD (RGD-PM-OM).Then, tissue biodistribution behavior was investigated in mice by a developed a rapid, high selective UPLC-ESI-MS/MS method.

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Application of a UPLC-MS/MS method for the quantification of OM in rat tissue biodistribution after

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