【摘 要】
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Introduction: It has been shown that the major causes of erectile dysfunction (ED) associated with aging were via a diffuse and progressive corporal fibrosis to cavernous smooth muscle cells (CSMCs) i
【机 构】
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Department of Urology, Department of Infertility and Sexual Medicine, The Third Affiliated Hospital
【出 处】
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GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会
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Introduction: It has been shown that the major causes of erectile dysfunction (ED) associated with aging were via a diffuse and progressive corporal fibrosis to cavernous smooth muscle cells (CSMCs) in the penis.Previous studies have demonstrated that bone marrow-mesenchymal stromal cells (BM-MSCs) could possess the ability for selfrenewal, multiline age differentiation and in vivo functional regeneration of damaged tissues.It was suggested that they be induced to differentiate into smooth muscle-like cells in vitro and have a potential source for stem-cell-based gene therapy of ED.Specific phosphodiesterases (PDE5)has been proved to play an important role in regulating penile erection to return to flaccidity by hydrolysis of cyclic guanosine monophosphate (cGMP) as a specific hydratase.
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