【摘 要】
：
目的 支气管哮喘是严重威胁儿童生命健康的一种慢性呼吸道疾病,目前特异性免疫治疗被认为是唯一针对病因的治疗方法,近年来随着变应原试剂的标准化及治疗途径的多样化,其治疗的安全性及有效性越来越受到人们的重视.本研究通过比较经不同给药途径进行户尘螨特异性免疫治疗后患儿体内调节性T细胞的水平变化,旨在一定程度上为阐明特异性免疫治疗的临床免疫学机制以及评价其远期治疗效果提供依据.方法 收集2012年2月至20
【机 构】
：
首都医科大学附属北京儿童医院过敏反应科 北京市儿科研究所耳鼻喉头颈外科北京市重点实验室 10004
【出 处】
：
中华医学会2014年全国变态反应学术会议
论文部分内容阅读
目的 支气管哮喘是严重威胁儿童生命健康的一种慢性呼吸道疾病,目前特异性免疫治疗被认为是唯一针对病因的治疗方法,近年来随着变应原试剂的标准化及治疗途径的多样化,其治疗的安全性及有效性越来越受到人们的重视.本研究通过比较经不同给药途径进行户尘螨特异性免疫治疗后患儿体内调节性T细胞的水平变化,旨在一定程度上为阐明特异性免疫治疗的临床免疫学机制以及评价其远期治疗效果提供依据.方法 收集2012年2月至2013年10月在我院确诊为尘螨致敏的轻、中度哮喘患儿共计86例(男性63例,女性23例),分为4组:经舌下免疫治疗满1年的哮喘患儿共计29例(SLIT组:男女比例为22/8,平均年龄为9岁);经皮下免疫治疗满1年的哮喘患儿共计13例(SCIT组:男女比例为8/5,平均年龄为8岁,);结束SCIT足疗程3年后停止治疗1年以上的患儿共计14例(结束SCIT组:男女比例为14/0,平均年龄为7岁6月);未经免疫治疗而存在尘螨致敏的哮喘患儿共计30例,(对照组:男女比例为19/13,平均年龄为7岁5月).分离入选患儿的外周血淋巴细胞(PBMC),给予不同浓度(0μg/mL、2.5μg/mL、5μg/mL)户尘螨蛋白浸液(Der p1)刺激后,流式细胞术检测CD4+CD25+Foxp3+调节T淋巴细胞百分比水平.
其他文献
Background To observe whether there are some differences between Myocardial postconditioning and Remote postconditioning,and whether there is additional cardiac protection when they are used combined
Background The therapeutic efficiency of bone marrow mononuclear cells (BMMNCs) autologous transplantation for myocardial infarction (MI) remains low.Here we developed a novel strategy to improve card
Background Myocardial ischemia reperfusion (I/R) can induce altered expression of microRNAs (miRNAs).The miRNAs-miR-15a,miR-15b and miR-16 have been shown to play a role in apoptosis,although not in c
Background Activation of cardiac fibroblasts (CFs) and their differentiation into myofibroblasts (MCFs) is a crucial event in the progression of cardiac fibrosis after myocardial infarction that leads
Background Mesenchymal stem cells (MSCs) hold great promise for stem cell therapy and are gradually used in clinical trials in recent years.However,advanced age is a negative factor for autologous MSC
Background We adopt the lentiv-GFP,carrying green fluorescent,as a vector to study the characteristics of the pacemaker current in the MSCs co-transfected with different proportions of hHCN1 and hHCN4
Background Autophagy plays an important role in the development of angiotensin Ⅱ (Ang Ⅱ)-induced cardiac remodeling.However,the mechanism has not been completely understood.This study is designated to
Background Cell transplantation has emerged as a promising treatment for cardiac repair after myocardial infarction.However,efficient cell delivery to the targeted myocardium remains a practical chall
Background Retrograde coronary venous delivery of basic fibroblast growth factor (bFGF) or bone marrow mesenchymal stem cells (MSCs) have been demonstrated to target infarcted myocardium.The present s
Background Atherosclerosis and its complications are the major cause of mortality all over the world.It is reported recently that profilin-1,an intracellular actinbinding protein,plays a pivotal role