Active MERS-CoV replication and aberrant induction of inflammatory cytokines and chemokines in human

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Middle East respiratory syndrome coronavirus (MERS-CoV) caused severe pneumonia, multi-organ dysfunction and a higher fatality rate (50% versus 10%) than severe acute respiratory syndrome coronavirus (SARS-CoV).To understand the pathogenesis, we studied viral replication, cytokine/chemokine response and antigen presentation in MERS-CoVinfected human monocyte-derived macrophages (MDMs) versus SARS-CoV-infected-MDMs.Only MERS-CoV can replicate in MDMs.
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