Objective Lung cancer is the most common cause of cancer death worldwide and approximately a million people die from the disease each year; and becoming the leading cause of death in China.The change of nature environment may be the cause of the high incidence and death.This high prevalence translates to a significant societal and financial burden and highlights the great need to prevent and suppress lung cancer formation.Previous studies have shown that increased consumption dlimonene(DL)which comprises 90%of orange peel oil may reduce the risk of developing cancer.For colon cancer,d-limonene induced apoptosis via the mitochondrial death pathway and the suppression of the PI3K/Akt pathway.However,research upon the effort of DL on lung cancer is little.Little is also still known about the interaction of lncRNA and dietary factors.We hypothesized that lncRNAs could be a chemopreventive target of the phytochemical DL.Using RNA-sequencing(RNA-seq),we determined genome wide expression levels for lncRNAs and investigated whether these changes have functional importance.Additional we explored the cancer-relative pathways that DL may influence.