Nonresolving inflammation (NRI) plays an important role in the initiation, development and neoplastic transformation of tumors.The tumor microenvironment is a nonresolving inflammatory microenvironment, which would promote tumor malignant transformation induced by chronic, repeated and trace amounts of inflammatory stimulations.For the regulatory mechanism of tumor cells to the cells around them, the exosomes functioning as messengers are drawing more and more attentions.Currently, researchers believe that miRNAs can also mediate the cell-cell communications as signal molecules.In the tumor micro inflammatory environment, the tumor-derived exosomes-miRNAs exhibit critical functional regulation on the adjacent cells.Hence, exploring the formational and functional mechanisms of exosomes-miRNAs would help to unveil the core of immune and inflammation in tumor microenvironment, contributing to the research of targeted therapy based on tumor microenvironment.