2. 您的位置
3. 首页
4. 会议论文
5. Adaptive multi-factor multi-stage clinical trial methods

Adaptive multi-factor multi-stage clinical trial methods

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：hfzwl

【摘 要】

：

Efficacious and effective interventions usually involve multiple factors.And it is fantasy to have pilot information about the main effects and their interactions for all factors at the time of initia

【作 者】

：

Samuel S.Wu Abhishek Bhattacharjee Robert Mee 

【机 构】

：

Department of Biostatistics,University of Florida,Gainesville,FL 32610,USA.

【出 处】

：

上海交通大学

【发表日期】

：

2016年4期

【关键词】

：

factorial design clinical trial adaptive multi-stage 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Efficacious and effective interventions usually involve multiple factors.And it is fantasy to have pilot information about the main effects and their interactions for all factors at the time of initial study design.

其他文献

MRCT design models and drop-min data analysis

In recent years,developing pharmaceutical products via a multiregional clinical trial(MRCT)has become more popular.

会议

Combined treatment effect

Smart indexing under regime switching uncertainty:State-estimate risk optimization

Fund management based on index-tracking is well-studied and widely-practiced.Stock index funds represent more than 75% of index mutual funds valued over 1.7 trillion dollars.

会议

Index-trackingsmart indexingportfolio risk optimizationregime-switching uncer

Censoring Unbiased Survival Trees

Estimating a patients mortality risk is important in making treatment decisions.Treebased methods are useful tools to identify risk groups and conduct prediction by employing binary recursive partitio

会议

Classification and Regression TreesCensoring Unbiased TransformationDoubly Rob

An Adaptive Multi-stage Phase Ⅰ Dose-finding Design Incorporating Longitudinal Continuous Toxicity a

Phase Ⅰ designs traditionally use the dose-limiting toxicity(DLT),a binary endpoint based on the first treatment cycle,to locate the maximum-tolerated dose(MTD)assuming a monotonic relationship betwee

会议

Phase Ⅰ clinical trialDose-findingBayesian methodJoint modelingAdaptive desi

The Sampling Aspect of Uncertainty Quantification

Computer simulations based on computational fluid dynamics,finite element analysis,discrete element models and multi-physics codes are widely used in automotive,finance,data centers and many other app

会议

Uncertainty QuantificationDesign of ExperimentsSensitivity AnalysisComputer E

USING STRUCTURAL-NESTED MODELS TO ESTIMATE THE EFFECT OF CLUSTER-LEVEL ADHERENCE ON INDIVIDUAL-LEVEL

Much attention has been paid to estimating the causal effect of adherence to a randomized protocol using instrumental variables to adjust for unmeasured confounding.

会议

unmeasured confoundinginstrumental variablescomplex survey dataadherence

Spatio-Temporal Monitoring of Disease Incidence Data

To monitor the incidence rates of cancers,AIDS,cardiovascular diseases,and other chronicle or infectious diseases,some global,national and regional reporting systems have been built to collect/provide

会议

Infectious diseaseProcess monitoringSpatio-temporal data

STRUCTURED SUBCOMPOSITION SELECTION IN REGRESSION AND ITS APPLICATION TO MICROBIOME DATA ANALYSIS

Compositional data arise naturally in many practical problems and the analysis of such data presents many statistical challenges,especially in high dimensions.

会议

compositional data analysishomogeneitylog ratio transformationspenalized regr

A General Decision Theory for Huber's ∈-Contamination Model

Todays data pose unprecedented challenges to statisticians.It may be incomplete,corrupted or exposed to some unknown source of contamination.

会议

Robust statisticsRobust testingMinimax rateDensity estimationSparse linear r

Nonparametric Robust Statistics and Outlier Reset CUSUM for the Exploration of Copy Number Alteratio

Copy number alteration(CNA)data have been collected to study disease related chro-mosomal amplifications and deletions.

会议

copy number alterationCUSUMoutlier